Docking, thermodynamics and molecular dynamics (MD) studies of a non-canonical protease inhibitor, MP-4, from Mucuna pruriens

Sequence and structural homology suggests that MP-4 protein from Mucuna pruriens belongs to Kunitz-type protease inhibitor family. However, biochemical assays showed that this protein is a poor inhibitor of trypsin. To understand the basis of observed poor inhibition, thermodynamics and molecular dy...

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Detalles Bibliográficos
Autores principales: Kumar, Ashish, Kaur, Harmeet, Jain, Abha, Nair, Deepak T., Salunke, Dinakar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766534/
https://www.ncbi.nlm.nih.gov/pubmed/29330385
http://dx.doi.org/10.1038/s41598-017-18733-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766534/
https://www.ncbi.nlm.nih.gov/pubmed/29330385
http://dx.doi.org/10.1038/s41598-017-18733-9

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