Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity

Photochemical internalization (PCI) is a cellular drug delivery method based on the generation of light-induced reactive oxygen species (ROS) causing damage to the endosomal membrane and thereby resulting in drug release to the cytoplasm. In our study a series of antisense fluorophore octaarginine p...

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Detalles Bibliográficos
Autores principales: Yarani, Reza, Shiraishi, Takehiko, Nielsen, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766568/
https://www.ncbi.nlm.nih.gov/pubmed/29330463
http://dx.doi.org/10.1038/s41598-017-18947-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766568/
https://www.ncbi.nlm.nih.gov/pubmed/29330463
http://dx.doi.org/10.1038/s41598-017-18947-x

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