20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

The long-chain fatty acid receptor FFAR1 is highly expressed in pancreatic β-cells. Synthetic FFAR1 agonists can be used as antidiabetic drugs to promote glucose-stimulated insulin secretion (GSIS). However, the physiological role of FFAR1 in β-cells remains poorly understood. Here we show that 20-H...

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Detalles Bibliográficos
Autores principales: Tunaru, Sorin, Bonnavion, Remy, Brandenburger, Isabell, Preussner, Jens, Thomas, Dominique, Scholich, Klaus, Offermanns, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766607/
https://www.ncbi.nlm.nih.gov/pubmed/29330456
http://dx.doi.org/10.1038/s41467-017-02539-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766607/
https://www.ncbi.nlm.nih.gov/pubmed/29330456
http://dx.doi.org/10.1038/s41467-017-02539-4

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