Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in huma...

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Detalles Bibliográficos
Autores principales: Miranda, Cristobal L., Johnson, Lance A., de Montgolfier, Oriane, Elias, Valerie D., Ullrich, Lea S., Hay, Joshua J., Paraiso, Ines L., Choi, Jaewoo, Reed, Ralph L., Revel, Johana S., Kioussi, Chrissa, Bobe, Gerd, Iwaniec, Urszula T., Turner, Russell T., Katzenellenbogen, Benita S., Katzenellenbogen, John A., Blakemore, Paul R., Gombart, Adrian F., Maier, Claudia S., Raber, Jacob, Stevens, Jan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766630/
https://www.ncbi.nlm.nih.gov/pubmed/29330372
http://dx.doi.org/10.1038/s41598-017-18992-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766630/
https://www.ncbi.nlm.nih.gov/pubmed/29330372
http://dx.doi.org/10.1038/s41598-017-18992-6

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