Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate

African green monkey (AGM)-derived Vero cells have been utilized to produce various human vaccines. The Vero cell genome harbors a variety of simian endogenous type D retrovirus (SERV) sequences. In this study, a transcriptome analysis showed that DNA hypomethylation released the epigenetic repressi...

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Detalles Bibliográficos
Autores principales: Sakuma, Chisato, Sekizuka, Tsuyoshi, Kuroda, Makoto, Kasai, Fumio, Saito, Kyoko, Ikeda, Masaki, Yamaji, Toshiyuki, Osada, Naoki, Hanada, Kentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766633/
https://www.ncbi.nlm.nih.gov/pubmed/29330501
http://dx.doi.org/10.1038/s41598-017-18934-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766633/
https://www.ncbi.nlm.nih.gov/pubmed/29330501
http://dx.doi.org/10.1038/s41598-017-18934-2

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