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Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng

BACKGROUND: The use of different methods for the processing of ginseng can result in alterations in its medicinal properties and efficacy. White ginseng (WG), frozen ginseng (FG), and red ginseng (RG) are produced using different methods. WG, FG, and RG possess different pharmacological properties....

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Autores principales: Chen, Jianbo, Li, Meijia, Chen, Lixue, Wang, Yufang, Li, Shanshan, Zhang, Yuwei, Zhang, Lei, Song, Mingjie, Liu, Chang, Hua, Mei, Sun, Yinshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766692/
https://www.ncbi.nlm.nih.gov/pubmed/29348719
http://dx.doi.org/10.1016/j.jgr.2016.12.008
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author Chen, Jianbo
Li, Meijia
Chen, Lixue
Wang, Yufang
Li, Shanshan
Zhang, Yuwei
Zhang, Lei
Song, Mingjie
Liu, Chang
Hua, Mei
Sun, Yinshi
author_facet Chen, Jianbo
Li, Meijia
Chen, Lixue
Wang, Yufang
Li, Shanshan
Zhang, Yuwei
Zhang, Lei
Song, Mingjie
Liu, Chang
Hua, Mei
Sun, Yinshi
author_sort Chen, Jianbo
collection PubMed
description BACKGROUND: The use of different methods for the processing of ginseng can result in alterations in its medicinal properties and efficacy. White ginseng (WG), frozen ginseng (FG), and red ginseng (RG) are produced using different methods. WG, FG, and RG possess different pharmacological properties. METHODS: WG, FG, and RG extracts and pure ginsenosides were administered to rats to study the pharmacokinetics and tissue distribution characteristics of the following ginsenosides—Rg1, Re, Rb1, and Rd. The concentrations of the ginsenosides in the plasma and tissues were determined using UPLC-MS/MS. RESULTS: The rate and extent of absorption of Rg1, Re, Rb1, and Rd appeared to be affected by the different methods used in processing the ginseng samples. The areas under the plasma drug concentration-time curves (AUCs) of Rg1, Re, Rb1, and Rd were significantly higher than those of the pure ginsenosides. In addition, the AUCs of Rg1, Re, Rb1, and Rd were different for WG, FG, and RG. The amounts of Rg1, Re, Rd, and Rb1 were significantly (p < 0.05) higher in the tissues than those of the pure ginsenosides. The amounts of Re, Rb1, and Rd from the RG extract were significantly higher than those from the WG and FG extracts in the heart, lungs, and kidneys of the rats. CONCLUSION: Our results show that the use of different methods to process ginseng might affect the pharmacokinetics and oral bioavailability of ginseng as well as the tissue concentrations of Rg1, Re, Rd, and Rb1.
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spelling pubmed-57666922018-01-18 Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng Chen, Jianbo Li, Meijia Chen, Lixue Wang, Yufang Li, Shanshan Zhang, Yuwei Zhang, Lei Song, Mingjie Liu, Chang Hua, Mei Sun, Yinshi J Ginseng Res Research Article BACKGROUND: The use of different methods for the processing of ginseng can result in alterations in its medicinal properties and efficacy. White ginseng (WG), frozen ginseng (FG), and red ginseng (RG) are produced using different methods. WG, FG, and RG possess different pharmacological properties. METHODS: WG, FG, and RG extracts and pure ginsenosides were administered to rats to study the pharmacokinetics and tissue distribution characteristics of the following ginsenosides—Rg1, Re, Rb1, and Rd. The concentrations of the ginsenosides in the plasma and tissues were determined using UPLC-MS/MS. RESULTS: The rate and extent of absorption of Rg1, Re, Rb1, and Rd appeared to be affected by the different methods used in processing the ginseng samples. The areas under the plasma drug concentration-time curves (AUCs) of Rg1, Re, Rb1, and Rd were significantly higher than those of the pure ginsenosides. In addition, the AUCs of Rg1, Re, Rb1, and Rd were different for WG, FG, and RG. The amounts of Rg1, Re, Rd, and Rb1 were significantly (p < 0.05) higher in the tissues than those of the pure ginsenosides. The amounts of Re, Rb1, and Rd from the RG extract were significantly higher than those from the WG and FG extracts in the heart, lungs, and kidneys of the rats. CONCLUSION: Our results show that the use of different methods to process ginseng might affect the pharmacokinetics and oral bioavailability of ginseng as well as the tissue concentrations of Rg1, Re, Rd, and Rb1. Elsevier 2018-01 2017-01-11 /pmc/articles/PMC5766692/ /pubmed/29348719 http://dx.doi.org/10.1016/j.jgr.2016.12.008 Text en © 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Chen, Jianbo
Li, Meijia
Chen, Lixue
Wang, Yufang
Li, Shanshan
Zhang, Yuwei
Zhang, Lei
Song, Mingjie
Liu, Chang
Hua, Mei
Sun, Yinshi
Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title_full Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title_fullStr Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title_full_unstemmed Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title_short Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
title_sort effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766692/
https://www.ncbi.nlm.nih.gov/pubmed/29348719
http://dx.doi.org/10.1016/j.jgr.2016.12.008
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