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Monitoring Ca(2+) elevations in individual astrocytes upon local release of amyloid beta in acute brain slices
The pathogenesis of Alzheimer’s disease (AD) is thought to involve acute neurotoxic effects exerted by oligomeric forms of amyloid-β 1-42 (Aβ). Application of Aβ oligomers in physiological concentrations have been shown to transiently elevate internal Ca(2+) in cultured astroglia. While the cellular...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766740/ https://www.ncbi.nlm.nih.gov/pubmed/28011193 http://dx.doi.org/10.1016/j.brainresbull.2016.12.007 |