Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These stat...

Descripción completa

Detalles Bibliográficos
Autores principales: Imamovic, Lejla, Ellabaan, Mostafa Mostafa Hashim, Dantas Machado, Ana Manuel, Citterio, Linda, Wulff, Tune, Molin, Soren, Krogh Johansen, Helle, Sommer, Morten Otto Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766827/
https://www.ncbi.nlm.nih.gov/pubmed/29307490
http://dx.doi.org/10.1016/j.cell.2017.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766827/
https://www.ncbi.nlm.nih.gov/pubmed/29307490
http://dx.doi.org/10.1016/j.cell.2017.12.012

Ejemplares similares