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Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These stat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766827/ https://www.ncbi.nlm.nih.gov/pubmed/29307490 http://dx.doi.org/10.1016/j.cell.2017.12.012 |