δ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin

KEY POINTS: We used a mouse expressing a light‐sensitive ion channel in β‐cells to understand how α‐cell activity is regulated by β‐cells. Light activation of β‐cells triggered a suppression of α‐cell activity via gap junction‐dependent activation of δ‐cells. Mathematical modelling of human islets s...

Descripción completa

Detalles Bibliográficos
Autores principales: Briant, L. J. B., Reinbothe, T. M., Spiliotis, I., Miranda, C., Rodriguez, B., Rorsman, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Endocrine, Nutrition and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767697/
https://www.ncbi.nlm.nih.gov/pubmed/28975620
http://dx.doi.org/10.1113/JP274581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767697/
https://www.ncbi.nlm.nih.gov/pubmed/28975620
http://dx.doi.org/10.1113/JP274581

Ejemplares similares