Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono- and di-nucleotide frameshifts to classify it as microsatellite instabili...

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Detalles Bibliográficos
Autores principales: Koi, Minoru, Tseng-Rogenski, Stephanie S, Carethers, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767788/
https://www.ncbi.nlm.nih.gov/pubmed/29375743
http://dx.doi.org/10.4251/wjgo.v10.i1.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767788/
https://www.ncbi.nlm.nih.gov/pubmed/29375743
http://dx.doi.org/10.4251/wjgo.v10.i1.1

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