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Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono- and di-nucleotide frameshifts to classify it as microsatellite instabili...

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Detalles Bibliográficos
Autores principales:	Koi, Minoru, Tseng-Rogenski, Stephanie S, Carethers, John M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767788/ https://www.ncbi.nlm.nih.gov/pubmed/29375743 http://dx.doi.org/10.4251/wjgo.v10.i1.1

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