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Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo
Dengue, a significant public health problem in several countries around the world, is caused by four different serotypes of mosquito-borne dengue viruses (DENV-1, -2, -3, and -4). Antibodies to any one DENV serotype which can protect against homotypic re-infection, do not offer heterotypic cross-pro...
Autores principales: | Shukla, Rahul, Rajpoot, Ravi K., Arora, Upasana, Poddar, Ankur, Swaminathan, Sathyamangalam, Khanna, Navin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768101/ https://www.ncbi.nlm.nih.gov/pubmed/29367852 http://dx.doi.org/10.3389/fmicb.2017.02644 |
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