A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity

Kidney-type glutaminase (KGA), a mitochondrial enzyme converting glutamine to glutamate for energy supply, was over-expressed in many cancers and had been regarded as a promising therapeutic target in recent years. Structure-based virtual ligand screening predicted physapubescin K, a new withanolide...

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Detalles Bibliográficos
Autores principales: Wu, Canrong, Zheng, Mengzhu, Gao, Suyu, Luan, Shanshan, Cheng, Li, Wang, Liqing, Li, Jiachen, Chen, Lixia, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768343/
https://www.ncbi.nlm.nih.gov/pubmed/29371926
http://dx.doi.org/10.18632/oncotarget.23058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768343/
https://www.ncbi.nlm.nih.gov/pubmed/29371926
http://dx.doi.org/10.18632/oncotarget.23058

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