Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase

Type I interferons (IFN-α/β) have broad and potent immunoregulatory and antiproliferative activities, which are negatively regulated by Src homology domain 2 containing tyrosine phosphatase-2 (SHP-2). Inhibition of SHP2 by small molecules may be a new strategy to enhance the effcacy of type I IFNs....

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Detalles Bibliográficos
Autores principales: Igbe, Ighodaro, Shen, Xiao-Fei, Jiao, Wei, Qiang, Zhe, Deng, Teng, Li, Sheng, Liu, Wan-Li, Liu, Han-Wei, Zhang, Guo-Lin, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768359/
https://www.ncbi.nlm.nih.gov/pubmed/29371942
http://dx.doi.org/10.18632/oncotarget.22556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768359/
https://www.ncbi.nlm.nih.gov/pubmed/29371942
http://dx.doi.org/10.18632/oncotarget.22556

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