Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR(ser81) and CDK1 signaling: biological implications for men treated with testosterone replacement therapy

Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial. The effects of continuous or pulsed T stimulation were...

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Detalles Bibliográficos
Autores principales: Gravina, Giovanni Luca, Marampon, Francesco, Sanità, Patrizia, Festuccia, Claudio, Forcella, Chiara, Scarsella, Luca, Jitariuc, Anna, Vetuschi, Antonella, Sferra, Roberta, Colapietro, Alessandro, Carosa, Eleonora, Dolci, Susanna, Lenzi, Andrea, Jannini, Emmanuele A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768363/
https://www.ncbi.nlm.nih.gov/pubmed/29371946
http://dx.doi.org/10.18632/oncotarget.22776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768363/
https://www.ncbi.nlm.nih.gov/pubmed/29371946
http://dx.doi.org/10.18632/oncotarget.22776

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