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PERK-mediated translational control is required for collagen secretion in chondrocytes

As chondrocytes are highly secretory and they experience a variety of stresses, physiological unfolded protein response (UPR) signalling is essential for extracellular matrix (ECM) secretion and chondrogenesis. In the three branches of the UPR pathway, PERK governs the translational attenuation and...

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Detalles Bibliográficos
Autores principales: Hisanaga, Satoshi, Miyake, Masato, Taniuchi, Shusuke, Oyadomari, Miho, Morimoto, Masatoshi, Sato, Ryosuke, Hirose, Jun, Mizuta, Hiroshi, Oyadomari, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768675/
https://www.ncbi.nlm.nih.gov/pubmed/29335505
http://dx.doi.org/10.1038/s41598-017-19052-9