Cell-type specific potent Wnt signaling blockade by bispecific antibody

Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development. Using the Wnt/β-catenin signaling pathway as a model system, we report here a nov...

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Detalles Bibliográficos
Autores principales: Lee, Nam-Kyung, Zhang, Yafeng, Su, Yang, Bidlingmaier, Scott, Sherbenou, Daniel W., Ha, Kevin D., Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768681/
https://www.ncbi.nlm.nih.gov/pubmed/29335534
http://dx.doi.org/10.1038/s41598-017-17539-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768681/
https://www.ncbi.nlm.nih.gov/pubmed/29335534
http://dx.doi.org/10.1038/s41598-017-17539-z

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