Phosphorylation-induced conformation of β(2)-adrenoceptor related to arrestin recruitment revealed by NMR

The C-terminal region of G-protein-coupled receptors (GPCRs), stimulated by agonist binding, is phosphorylated by GPCR kinases, and the phosphorylated GPCRs bind to arrestin, leading to the cellular responses. To understand the mechanism underlying the formation of the phosphorylated GPCR-arrestin c...

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Detalles Bibliográficos
Autores principales: Shiraishi, Yutaro, Natsume, Mei, Kofuku, Yutaka, Imai, Shunsuke, Nakata, Kunio, Mizukoshi, Toshimi, Ueda, Takumi, Iwaï, Hideo, Shimada, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768704/
https://www.ncbi.nlm.nih.gov/pubmed/29335412
http://dx.doi.org/10.1038/s41467-017-02632-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768704/
https://www.ncbi.nlm.nih.gov/pubmed/29335412
http://dx.doi.org/10.1038/s41467-017-02632-8

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