Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation

The TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizing E. coli Nissle (EcN), which induces severe inflammation in germfree TLR4(−/−) mice. After monoassociation, EcN was detected in spleens and livers of TLR4(−/−) and...

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Detalles Bibliográficos
Autores principales: Basic, Marijana, Buettner, Manuela, Keubler, Lydia M., Smoczek, Anna, Bruesch, Inga, Buchheister, Stephanie, Bleich, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768714/
https://www.ncbi.nlm.nih.gov/pubmed/29335601
http://dx.doi.org/10.1038/s41598-017-19062-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768714/
https://www.ncbi.nlm.nih.gov/pubmed/29335601
http://dx.doi.org/10.1038/s41598-017-19062-7

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