Analysis of the HIV-2 protease’s adaptation to various ligands: characterization of backbone asymmetry using a structural alphabet

The HIV-2 protease (PR2) is a homodimer of 99 residues with asymmetric assembly and binding various ligands. We propose an exhaustive study of the local structural asymmetry between the two monomers of all available PR2 structures complexed with various inhibitors using a structural alphabet approac...

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Detalles Bibliográficos
Autores principales: Triki, Dhoha, Cano Contreras, Mario Enrique, Flatters, Delphine, Visseaux, Benoit, Descamps, Diane, Camproux, Anne-Claude, Regad, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768731/
https://www.ncbi.nlm.nih.gov/pubmed/29335428
http://dx.doi.org/10.1038/s41598-017-18941-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768731/
https://www.ncbi.nlm.nih.gov/pubmed/29335428
http://dx.doi.org/10.1038/s41598-017-18941-3

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