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Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768759/ https://www.ncbi.nlm.nih.gov/pubmed/29335501 http://dx.doi.org/10.1038/s41598-017-19095-y |