USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specific deubiquitinating enzymes (DUBs) are known to antagonize this function. Here we identify ubiquitin specific protease...

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Detalles Bibliográficos
Autores principales: Uckelmann, Michael, Densham, Ruth M., Baas, Roy, Winterwerp, Herrie H. K., Fish, Alexander, Sixma, Titia K., Morris, Joanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768779/
https://www.ncbi.nlm.nih.gov/pubmed/29335415
http://dx.doi.org/10.1038/s41467-017-02653-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768779/
https://www.ncbi.nlm.nih.gov/pubmed/29335415
http://dx.doi.org/10.1038/s41467-017-02653-3

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