Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

The mitogen-activated protein kinase (MAPK) pathway is frequently aberrantly activated in advanced cancers, including metastatic prostate cancer (CaP). However, activating mutations or gene rearrangements among MAPK signaling components, such as Ras and Raf, are not always observed in cancers with h...

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Detalles Bibliográficos
Autores principales: Chen, Ming, Wan, Lixin, Zhang, Jiangwen, Zhang, Jinfang, Mendez, Lourdes, Clohessy, John G., Berry, Kelsey, Victor, Joshua, Yin, Qing, Zhu, Yuan, Wei, Wenyi, Pandolfi, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768788/
https://www.ncbi.nlm.nih.gov/pubmed/29335436
http://dx.doi.org/10.1038/s41467-017-02272-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768788/
https://www.ncbi.nlm.nih.gov/pubmed/29335436
http://dx.doi.org/10.1038/s41467-017-02272-y

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