Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma

Pemetrexed is indicated for non-small cell lung carcinoma and mesothelioma, but often has limited efficacy due to drug resistance. To probe the molecular mechanisms underlying chemotherapeutic response, we performed mRNA and microRNA (miRNA) expression profiling of pemetrexed treated and untreated l...

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Detalles Bibliográficos
Autores principales: Gamazon, Eric R., Trendowski, Matthew R., Wen, Yujia, Wing, Claudia, Delaney, Shannon M., Huh, Won, Wong, Shan, Cox, Nancy J., Dolan, M. Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768793/
https://www.ncbi.nlm.nih.gov/pubmed/29335598
http://dx.doi.org/10.1038/s41598-017-19004-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768793/
https://www.ncbi.nlm.nih.gov/pubmed/29335598
http://dx.doi.org/10.1038/s41598-017-19004-3

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