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Expandable Arterial Endothelial Precursors from Human CD34(+) Cells Differ in Their Proclivity to Undergo an Endothelial-to-Mesenchymal Transition

Arterial diseases continue to pose a major health concern but in vitro studies are limited because explanted cells can exhibit poor proliferative capacity and a loss of specificity. Here, we find that two transcription factors, MYCN and SOX17, induce and indefinitely expand in culture precursors of...

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Detalles Bibliográficos
Autores principales: Miller, Auston Z., Satchie, Alexander, Tannenbaum, Alex P., Nihal, Aman, Thomson, James A., Vereide, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769011/
https://www.ncbi.nlm.nih.gov/pubmed/29320761
http://dx.doi.org/10.1016/j.stemcr.2017.12.011