Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

BACKGROUND: About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in  decreased mRNA abundance due to  nonsense...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Lulu, Low, Audrey, Damle, Sagar S., Keenan, Melissa M., Kuntz, Steven, Murray, Susan F., Monia, Brett P., Guo, Shuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769327/
https://www.ncbi.nlm.nih.gov/pubmed/29334995
http://dx.doi.org/10.1186/s13059-017-1386-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769327/
https://www.ncbi.nlm.nih.gov/pubmed/29334995
http://dx.doi.org/10.1186/s13059-017-1386-9

Ejemplares similares