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Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

BACKGROUND: Canonical Wnt/beta-catenin signalling regulates self-renewal and lineage selection within the mammalian epidermis. Although the transcriptional response of keratinocytes that receive a Wnt signal is well characterized, little is known about the mechanism by which keratinocytes in proximi...

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Detalles Bibliográficos
Autores principales: Ghahramani, Arsham, Donati, Giacomo, Luscombe, Nicholas M., Watt, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769491/
https://www.ncbi.nlm.nih.gov/pubmed/29334988
http://dx.doi.org/10.1186/s13059-017-1384-y