In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice

BACKGROUND: Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, has been shown to play a role in the pathophysiology of rheumatoid arthritis. Silencing TNFα expression with small interfering RNA (siRNA) is a promising approach to treatment of the condition. METHODS: Towards this end, ou...

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Detalles Bibliográficos
Autores principales: Shi, Qin, Rondon-Cavanzo, Elsa-Patricia, Dalla Picola, Isadora Pfeifer, Tiera, Marcio José, Zhang, Xiaoling, Dai, Kerong, Benabdoune, Houda Abir, Benderdour, Mohamed, Fernandes, Julio Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769564/
https://www.ncbi.nlm.nih.gov/pubmed/29391796
http://dx.doi.org/10.2147/IJN.S146942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769564/
https://www.ncbi.nlm.nih.gov/pubmed/29391796
http://dx.doi.org/10.2147/IJN.S146942

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