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In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice

BACKGROUND: Tumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, has been shown to play a role in the pathophysiology of rheumatoid arthritis. Silencing TNFα expression with small interfering RNA (siRNA) is a promising approach to treatment of the condition. METHODS: Towards this end, ou...

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Detalles Bibliográficos
Autores principales:	Shi, Qin, Rondon-Cavanzo, Elsa-Patricia, Dalla Picola, Isadora Pfeifer, Tiera, Marcio José, Zhang, Xiaoling, Dai, Kerong, Benabdoune, Houda Abir, Benderdour, Mohamed, Fernandes, Julio Cesar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769564/ https://www.ncbi.nlm.nih.gov/pubmed/29391796 http://dx.doi.org/10.2147/IJN.S146942

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