Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with progressive ataxia that affects both the peripheral and central nervous system (CNS). While later CNS neuropathology involves loss of large principal neurons and glutamatergic and GABAergic synaptic terminals in the c...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Hong, Magrane, Jordi, Clark, Elisia M., Halawani, Sarah M., Warren, Nathan, Rattelle, Amy, Lynch, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769605/
https://www.ncbi.nlm.nih.gov/pubmed/29259026
http://dx.doi.org/10.1242/dmm.030049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769605/
https://www.ncbi.nlm.nih.gov/pubmed/29259026
http://dx.doi.org/10.1242/dmm.030049

Ejemplares similares