A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism

Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to the kinase Akt (Akt1) to block its phosphorylation activation and reduce downstream insulin-stimulated ana...

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Detalles Bibliográficos
Autores principales: Fischer, Zachary, Das, Rahul, Shipman, Anna, Fan, Jin-Yuan, Pence, Laramie, Bouyain, Samuel, Dobens, Leonard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769606/
https://www.ncbi.nlm.nih.gov/pubmed/29025897
http://dx.doi.org/10.1242/dmm.030619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769606/
https://www.ncbi.nlm.nih.gov/pubmed/29025897
http://dx.doi.org/10.1242/dmm.030619

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