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A microRNA feedback loop regulates global microRNA abundance during aging

Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcrip...

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Detalles Bibliográficos
Autores principales: Inukai, Sachi, Pincus, Zachary, de Lencastre, Alexandre, Slack, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769744/
https://www.ncbi.nlm.nih.gov/pubmed/29114017
http://dx.doi.org/10.1261/rna.062190.117