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Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life. The structural destabilization of crystallins by UV exposure, glyc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770019/ https://www.ncbi.nlm.nih.gov/pubmed/29338044 http://dx.doi.org/10.1371/journal.pone.0190817 |