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A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant
Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by mutation of the A-T mutated (ATM) gene. ATM encodes a protein kinase that is activated by DNA damage and phosphorylates many proteins, including those involved in DNA repair, cell cycle control, and apoptosis. Characteristic biolog...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770031/ https://www.ncbi.nlm.nih.gov/pubmed/29338042 http://dx.doi.org/10.1371/journal.pone.0190821 |