Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

Female sex and history of prior pregnancies are associated with favorable melanoma outcomes. Here, we show that much of the melanoma protective effect likely results from estrogen signaling through the G protein-coupled estrogen receptor (GPER) on melanocytes. Selective GPER activation in primary me...

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Detalles Bibliográficos
Autores principales: Natale, Christopher A, Li, Jinyang, Zhang, Junqian, Dahal, Ankit, Dentchev, Tzvete, Stanger, Ben Z, Ridky, Todd W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770157/
https://www.ncbi.nlm.nih.gov/pubmed/29336307
http://dx.doi.org/10.7554/eLife.31770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770157/
https://www.ncbi.nlm.nih.gov/pubmed/29336307
http://dx.doi.org/10.7554/eLife.31770

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