Characterisation of endogenous A(2A) and A(2B) receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: Evidence for an allosteric mechanism of action for the A(2B)-selective antagonist PSB 603

Endogenous adenosine A(2B) receptors (A(2B)AR) mediate cAMP accumulation in HEK 293 cells. Here we have used a biosensor to investigate the mechanism of action of the A(2B)AR antagonist PSB 603 in HEK 293 cells. The A(2A) agonist CGS 21680 elicited a small response in these cells (circa 20% of that...

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Detalles Bibliográficos
Autores principales: Goulding, Joelle, May, Lauren T., Hill, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770336/
https://www.ncbi.nlm.nih.gov/pubmed/29106905
http://dx.doi.org/10.1016/j.bcp.2017.10.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770336/
https://www.ncbi.nlm.nih.gov/pubmed/29106905
http://dx.doi.org/10.1016/j.bcp.2017.10.013

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