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Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains
Background: Development of improved therapeutics against tuberculosis (TB) is hindered by an inadequate understanding of the relationship between disease severity and genetic diversity of its causative agent, Mycobacterium tuberculosis. We previously isolated a hypervirulent M. tuberculosis strain H...
Autores principales: | Rajwani, Rahim, Yam, Wing Cheong, Zhang, Ying, Kang, Yu, Wong, Barry Kin Chung, Leung, Kenneth Siu Sing, Tam, Kingsley King Gee, Tulu, Ketema Tafess, Zhu, Li, Siu, Gilman Kit Hang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770396/ https://www.ncbi.nlm.nih.gov/pubmed/29376038 http://dx.doi.org/10.3389/fcimb.2017.00539 |
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