Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for the development of effective strategies for treating tumors and chronic infections. The molecular processes that occur in responder T cells that are suppressed by Treg cells are unclear. Here we show that human Tre...

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Detalles Bibliográficos
Autores principales: Liu, Xia, Mo, Wei, Ye, Jian, Li, Lingyun, Zhang, Yanping, Hsueh, Eddy C., Hoft, Daniel F., Peng, Guangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770447/
https://www.ncbi.nlm.nih.gov/pubmed/29339767
http://dx.doi.org/10.1038/s41467-017-02689-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770447/
https://www.ncbi.nlm.nih.gov/pubmed/29339767
http://dx.doi.org/10.1038/s41467-017-02689-5

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