Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling

The capacity of HIV-1 to develop resistance to current drugs calls for innovative strategies to control this infection. We aimed at developing novel inhibitors of HIV-1 replication by targeting viral RNA processing—a stage dependent on conserved host processes. We previously reported that digoxin is...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Raymond W., Lingwood, Clifford A., Ostrowski, Mario A., Cabral, Tyler, Cochrane, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770468/
https://www.ncbi.nlm.nih.gov/pubmed/29339801
http://dx.doi.org/10.1038/s41598-018-19298-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770468/
https://www.ncbi.nlm.nih.gov/pubmed/29339801
http://dx.doi.org/10.1038/s41598-018-19298-x

Ejemplares similares