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Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling

The capacity of HIV-1 to develop resistance to current drugs calls for innovative strategies to control this infection. We aimed at developing novel inhibitors of HIV-1 replication by targeting viral RNA processing—a stage dependent on conserved host processes. We previously reported that digoxin is...

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Detalles Bibliográficos
Autores principales:	Wong, Raymond W., Lingwood, Clifford A., Ostrowski, Mario A., Cabral, Tyler, Cochrane, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770468/ https://www.ncbi.nlm.nih.gov/pubmed/29339801 http://dx.doi.org/10.1038/s41598-018-19298-x

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