The association of low penetrance genetic risk modifiers with colorectal cancer in lynch syndrome patients: a systematic review and meta-analysis

Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome accounting for approximately 1000 cases of colorectal cancer (CRC) in the UK annually. LS is characterised by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. The penetrance is highl...

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Detalles Bibliográficos
Autores principales: Donald, Neil, Malik, Salim, McGuire, Joshua L., Monahan, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770497/
https://www.ncbi.nlm.nih.gov/pubmed/28508326
http://dx.doi.org/10.1007/s10689-017-9995-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770497/
https://www.ncbi.nlm.nih.gov/pubmed/28508326
http://dx.doi.org/10.1007/s10689-017-9995-8

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