Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens against Plasmodium falciparum and Toxoplasma gondii, we report phenotype-...

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Detalles Bibliográficos
Autores principales: Subramanian, Gowtham, Belekar, Meenakshi A., Shukla, Anurag, Tong, Jie Xin, Sinha, Ameya, Chu, Trang T. T., Kulkarni, Akshay S., Preiser, Peter R., Reddy, D. Srinivasa, Tan, Kevin S. W., Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770543/
https://www.ncbi.nlm.nih.gov/pubmed/29359192
http://dx.doi.org/10.1128/mSphere.00534-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770543/
https://www.ncbi.nlm.nih.gov/pubmed/29359192
http://dx.doi.org/10.1128/mSphere.00534-17

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