Small molecules targeted to the microtubule–Hec1 interaction inhibit cancer cell growth through microtubule stabilization

Highly expressed in cancer protein 1 (Hec1) is a subunit of the kinetochore (KT)-associated Ndc80 complex, which ensures proper segregation of sister chromatids at mitosis by mediating the interaction between KTs and microtubules (MTs). HEC1 mRNA and protein are highly expressed in many malignancies...

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Detalles Bibliográficos
Autores principales: Ferrara, M, Sessa, G, Fiore, M, Bernard, F, Asteriti, I A, Cundari, E, Colotti, G, Ferla, S, Desideri, M, Buglioni, S, Trisciuoglio, D, Del Bufalo, D, Brancale, A, Degrassi, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770598/
https://www.ncbi.nlm.nih.gov/pubmed/28925395
http://dx.doi.org/10.1038/onc.2017.320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770598/
https://www.ncbi.nlm.nih.gov/pubmed/28925395
http://dx.doi.org/10.1038/onc.2017.320

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