Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking

Anoikis acts as a critical barrier to metastasis by inducing cell death upon cancer cell detachment from the extracellular matrix (ECM), thereby preventing tumor cell dissemination to secondary sites. The induction of anoikis requires the lysosomal-mediated downregulation of epidermal growth factor...

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Detalles Bibliográficos
Autores principales: Corkery, D P, Clarke, L E, Gebremeskel, S, Salsman, J, Pinder, J, Le Page, C, Meunier, L, Xu, Z, Mes-Masson, A-M, Berman, J N, Johnston, B, Dellaire, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770602/
https://www.ncbi.nlm.nih.gov/pubmed/28892043
http://dx.doi.org/10.1038/onc.2017.318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770602/
https://www.ncbi.nlm.nih.gov/pubmed/28892043
http://dx.doi.org/10.1038/onc.2017.318

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