Cargando…

Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases

In recent years, a substantial body of evidence has emerged demonstrating that purine and pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal development and organogenesis. Dynamic and time-dependent changes in the expression of purine metabolizing enzymes (such a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fumagalli, Marta, Lecca, Davide, Abbracchio, Maria P., Ceruti, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770749/ https://www.ncbi.nlm.nih.gov/pubmed/29375373 http://dx.doi.org/10.3389/fphar.2017.00941

Ejemplares similares

Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis?
por: Lecca, Davide, et al.
Publicado: (2021)

Purines in Pain as a Gliopathy
por: Magni, Giulia, et al.
Publicado: (2021)

Purinergic transmission in brain tumors and its impact on drug development
por: Abbracchio, Maria, et al.
Publicado: (2015)

Editorial: Astrocytes, a Kaleidoscope of Diversities, a Pharmacological Horizon
por: Di Cesare Mannelli, Lorenzo, et al.
Publicado: (2021)

Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain: Role of Microglia
por: Magni, Giulia, et al.
Publicado: (2018)

The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock
por: Abbracchio, Maria P.
Publicado: (2020)

Stretches of alternating pyrimidine/purines and purines are respectively linked with pathogenicity and growth temperature in prokaryotes
por: Bohlin, Jon, et al.
Publicado: (2009)

Biophysics, pathophysiology, and pharmacology of ion channel gating pores
por: Moreau, Adrien, et al.
Publicado: (2014)

The Effects of Injection of Purine and Pyrimidine Compounds on Grafted Mice
por: Barker, G. R., et al.
Publicado: (1949)

PURINE AND PYRIMIDINE CONTENTS OF SOME DESOXYPENTOSE NUCLEIC ACIDS
por: Daly, M. M., et al.
Publicado: (1950)

Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets
por: Nam, Inho, et al.
Publicado: (2018)

A Prebiotic Synthesis of Canonical Pyrimidine and Purine Ribonucleotides
por: Kim, Hyo-Joong, et al.
Publicado: (2019)

Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes
por: Mazzola, Alessia, et al.
Publicado: (2008)

P1 receptors and cytokine secretion
por: Abbracchio, Maria P., et al.
Publicado: (2007)

Roles of P2 receptors in glial cells: focus on astrocytes
por: Abbracchio, Maria P., et al.
Publicado: (2006)

Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology
por: Xiao, Qing-Ao, et al.
Publicado: (2022)

Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis
por: Ulrich, Henning, et al.
Publicado: (2018)

Boronated Pyrimidines and Purines as Cytotoxic, Hypolipidemic and Anti-Inflammatory Agents
por: Hall, Iris H., et al.
Publicado: (1996)

Purine and pyrimidine metabolism in human gliomas: relation to chromosomal aberrations.
por: Bardot, V., et al.
Publicado: (1994)

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
por: Stairs, Shaun, et al.
Publicado: (2017)

Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells
por: Marangon, Davide, et al.
Publicado: (2022)

Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools
por: Adzic, Marija, et al.
Publicado: (2018)

Purines and Carotid Body: New Roles in Pathological Conditions
por: Conde, Silvia V., et al.
Publicado: (2017)

The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients
por: Angelini, Jacopo, et al.
Publicado: (2021)

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System
por: Marangon, Davide, et al.
Publicado: (2021)

Asymmetric purine-pyrimidine distribution in cellular small RNA population of papaya
por: Aryal, Rishi, et al.
Publicado: (2012)

Anti‐flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues
por: McGuigan, Christopher, et al.
Publicado: (2016)

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation
por: Liang, Yong, et al.
Publicado: (2015)

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides
por: Rao, Jagadeeshwar R., et al.
Publicado: (2007)

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites
por: Oba, Yasuhiro, et al.
Publicado: (2022)

Inflammatory Bowel Disease and Risk of Colorectal Cancer: An Overview From Pathophysiology to Pharmacological Prevention
por: Lucafò, Marianna, et al.
Publicado: (2021)

Guanine-Based Purines as an Innovative Target to Treat Major Depressive Disorder
por: Almeida, Roberto F., et al.
Publicado: (2021)

Unveiling the Pharmacological Mechanisms of Eleutheroside E Against Postmenopausal Osteoporosis Through UPLC-Q/TOF-MS-Based Metabolomics
por: Ma, Yong-Sheng, et al.
Publicado: (2020)

Evaluating the Accuracy of the QCEIMS Approach for Computational Prediction of Electron Ionization Mass Spectra of Purines and Pyrimidines
por: Lee, Jesi, et al.
Publicado: (2022)

Brain tissue oxygen reactivity: clinical implications and pathophysiology
por: Harutyunyan, Gurgen, et al.
Publicado: (2014)

Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots
por: Bagshaw, Andrew TM, et al.
Publicado: (2006)

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)
por: Maity, Jyotirmoy, et al.
Publicado: (2013)

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors
por: Valle-Casuso, José-Carlos, et al.
Publicado: (2020)

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
por: Hasaneen, Noha, et al.
Publicado: (2019)

Dynamic Alterations of the Gut Microbial Pyrimidine and Purine Metabolism in the Development of Liver Cirrhosis
por: Xiong, Yinghui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gve15pekc3q1770n8nfbmqtr56