Cargando…

R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice

Human chromosome 16p11.2 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk for intellectual disability (ID) and autism spectrum disorder (ASD) and affects an estimated 3 in 10 000 people. Caused by a single copy deletion of ~27 genes, 16p11.2 microdeletio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stoppel, Laura J, Kazdoba, Tatiana M, Schaffler, Melanie D, Preza, Anthony R, Heynen, Arnold, Crawley, Jacqueline N, Bear, Mark F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770771/ https://www.ncbi.nlm.nih.gov/pubmed/28984295 http://dx.doi.org/10.1038/npp.2017.236

Ejemplares similares

Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome
por: Gundersen, Brigitta B., et al.
Publicado: (2023)

Contribution of mGluR5 to hippocampal pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion
por: Tian, Di, et al.
Publicado: (2015)

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks
por: Yang, Mu, et al.
Publicado: (2015)

Sensory processing in 16p11.2 deletion and 16p11.2 duplication
por: Smith, Harriet, et al.
Publicado: (2022)

Visual processing deficits in 22q11.2 Deletion Syndrome
por: Biria, Marjan, et al.
Publicado: (2017)

Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

Abnormal auditory and language pathways in children with 16p11.2 deletion
por: Berman, Jeffrey I., et al.
Publicado: (2015)

Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions
por: Demopoulos, Carly, et al.
Publicado: (2018)

Correction: Psychiatric disorders in children with 16p11.2 deletion and duplication
por: Niarchou, Maria, et al.
Publicado: (2019)

Adult Height, 22q11.2 Deletion Extent, and Short Stature in 22q11.2 Deletion Syndrome
por: Heung, Tracy, et al.
Publicado: (2022)

Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity
por: Perrone, Laura, et al.
Publicado: (2010)

16p11.2 deletion in patients with paroxysmal kinesigenic dyskinesia but without intellectual disability
por: Li, Wen, et al.
Publicado: (2018)

Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome
por: Welby, Lauren, et al.
Publicado: (2020)

Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology
por: Morrison, Sinead, et al.
Publicado: (2020)

Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications
por: Hudac, Caitlin M., et al.
Publicado: (2015)

Deletion and duplication of 16p11.2 are associated with opposing effects on visual evoked potential amplitude
por: LeBlanc, Jocelyn J., et al.
Publicado: (2016)

Clinical Characteristics of Seizures and Epilepsy in Individuals With Recurrent Deletions and Duplications in the 16p11.2 Region
por: Moufawad El Achkar, Christelle, et al.
Publicado: (2022)

The clinical presentation of attention deficit‐hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome
por: Niarchou, Maria, et al.
Publicado: (2015)

An affected core drives network integration deficits of the structural connectome in 22q11.2 deletion syndrome
por: Váša, František, et al.
Publicado: (2015)

mGluR5 Negative Modulators for Fragile X: Treatment Resistance and Persistence
por: Stoppel, David C., et al.
Publicado: (2021)

TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model
por: Scharrenberg, Robin, et al.
Publicado: (2022)

Reversal of Synaptic and Behavioral Deficits in a 16p11.2 Duplication Mouse Model via Restoration of the GABA Synapse Regulator Npas4
por: Rein, Benjamin, et al.
Publicado: (2020)

Hematological abnormalities and 22q11.2 deletion syndrome
por: Rosa, Rafael Fabiano Machado, et al.
Publicado: (2011)

Obesity in adults with 22q11.2 deletion syndrome
por: Voll, S, et al.
Publicado: (2016)

Risk of malignancy in 22q11.2 deletion syndrome
por: Stevens, Toer, et al.
Publicado: (2017)

The Genetics and Epigenetics of 22q11.2 Deletion Syndrome
por: Du, Qiumei, et al.
Publicado: (2020)

Complement Activation in 22q11.2 Deletion Syndrome
por: Grinde, Dina, et al.
Publicado: (2020)

Laryngeal web with 22q11.2 deletion syndrome
por: Abe, Yasuhiro, et al.
Publicado: (2022)

Tonsillectomy in Children with 22q11.2 Deletion Syndrome
por: Arganbright, Jill M., et al.
Publicado: (2022)

A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders
por: Zufferey, Flore, et al.
Publicado: (2012)

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes
por: Arbogast, Thomas, et al.
Publicado: (2016)

Male‐specific alterations in structure of isolation call sequences of mouse pups with 16p11.2 deletion
por: Agarwalla, Swapna, et al.
Publicado: (2020)

Hyperinsulinism in a patient with a Zellweger Spectrum Disorder and a 16p11.2 deletion syndrome
por: Hoytema van Konijnenburg, Eva M.M., et al.
Publicado: (2020)

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
por: Abel, Ted, et al.
Publicado: (2023)

Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome
por: Niarchou, Maria, et al.
Publicado: (2019)

Quantitative gait assessment in children with 16p11.2 syndrome
por: Goldman, Sylvie, et al.
Publicado: (2019)

Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits
por: Vysotskiy, Mikhail, et al.
Publicado: (2023)

Microduplications of 16p11.2 are Associated with Schizophrenia
por: McCarthy, Shane, et al.
Publicado: (2009)

Shyness discriminates between children with 22q11.2 deletion syndrome and Williams syndrome and predicts emergence of psychosis in 22q11.2 deletion syndrome
por: Schonherz, Yael, et al.
Publicado: (2014)

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder
por: Brunner, Daniela, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4fpm3akp2rg00atn2b6l6vo7hk