Human CD8(+) EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK

Cellular senescence is accompanied by a senescence‐associated secretory phenotype (SASP). We show here that primary human senescent CD8(+) T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contribute to age‐...

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Detalles Bibliográficos
Autores principales: Callender, Lauren A., Carroll, Elizabeth C., Beal, Robert W. J., Chambers, Emma S., Nourshargh, Sussan, Akbar, Arne N., Henson, Sian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770853/
https://www.ncbi.nlm.nih.gov/pubmed/29024417
http://dx.doi.org/10.1111/acel.12675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770853/
https://www.ncbi.nlm.nih.gov/pubmed/29024417
http://dx.doi.org/10.1111/acel.12675

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