Tyrosine phosphorylation of Munc18‐1 inhibits synaptic transmission by preventing SNARE assembly

Tyrosine kinases are important regulators of synaptic strength. Here, we describe a key component of the synaptic vesicle release machinery, Munc18‐1, as a phosphorylation target for neuronal Src family kinases (SFKs). Phosphomimetic Y473D mutation of a SFK phosphorylation site previously identified...

Descripción completa

Detalles Bibliográficos
Autores principales: Meijer, Marieke, Dörr, Bernhard, Lammertse, Hanna CA, Blithikioti, Chrysanthi, van Weering, Jan RT, Toonen, Ruud FG, Söllner, Thomas H, Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770875/
https://www.ncbi.nlm.nih.gov/pubmed/29150433
http://dx.doi.org/10.15252/embj.201796484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770875/
https://www.ncbi.nlm.nih.gov/pubmed/29150433
http://dx.doi.org/10.15252/embj.201796484

Ejemplares similares