Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality

The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age‐associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression...

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Detalles Bibliográficos
Autores principales: Qiu, Danhong, Hou, Xiaojing, Han, Longsen, Li, Xiaoyan, Ge, Juan, Wang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770883/
https://www.ncbi.nlm.nih.gov/pubmed/29067790
http://dx.doi.org/10.1111/acel.12698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770883/
https://www.ncbi.nlm.nih.gov/pubmed/29067790
http://dx.doi.org/10.1111/acel.12698

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